Protein Details: Voltage-gated sodium channel subunit alpha Nav1.4a

Protein ID

ICDB_Pro_0916

Protein Name

Voltage-gated sodium channel subunit alpha Nav1.4a

Gene Name

scn4aa; nav1.4a

Organism

Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

Length

1892 amino acids

AlphaFoldDB

AF-Q2XVR7-F1-model_v4.pdb

Function

Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting; activated and inactivated states. Required for normal muscle fiber excitability; normal muscle contraction and relaxation cycles.

Sequence

MATILPPPGTALFRHFTRQSLATIERLKEETLIAPKAGAHEEEEPPTPNPDLEAGKSLPMIFGDPPSELLGTPLEDIDPFYKAQKTFVVVTKGNTIYRFNAEPACYILSPFSLVRRGAIKILIHSLFSTLIMITILSNCVFMTMSNPPAWSKTVEYVFTGIYTFEATVKVLSRGFCVGPFTFLRDPWNWLDFMVISMAYITEFVDLGNVSALRTFRVLRALKTITVIPGLKTIVAALIQSVKKMVDVMILTVFALAVFALVGLQLFMGNLRHKCIRWPIANETASELFNGTVFNDTLSYNDTTWLNDTLDSNSTFDFTEYIENAENQYFLEGSKDALLCGNSTDAGKCPEGYLCMKAGRNPNYGYTSFDSFGWAFLALFRLMTQDNWESLFQLTLRAAGQTYMLFFVVVIFLGSFYLINLILAVVAMAYDEQNQASQQEAKEKEEEFQRLLEQLKNQEQAQVLGSRASLTSKKSVSLTGSDVADDEQSLENNEALKDCNGRPIPRLIIRAPTMKESAADYELREKEESSVHSVLHLDEPGLRERSASVATAAASVATAAASVATAAAMEELEEAQRPCPPIWYRFADIFLKWNCCEKWVVFKKWVHFVVMDPFVDLAITICIVLNTLFMAMEHYPMTEEFDYMLSVGNLVFTGIFAAEMFFKLIAMDPYYYFQVGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKISSDCELPRWHMNDFFHSFLIVFRILCGEWIETMWDCMEVAGAGMCLVVFMMVMVIGNLVVLNLFLALLLSSFSGDNLSVGDDDGELNNLQIAIGRITRGGNWLKAFLIGTVQRVLGREPQKPAEEDPADEGEGKTEGMEMNHLDGFKLADGIANCLVGGQPSGVTLDGESSITVPIALGESDSENPSEDDDDQEDDVDSEVTCEENEHHSDGVEDEFGVLQHVKLMGALTDGDSSVCSTVDYQPPEPEVQEEEEEEPDLVEPEACFTDNCVKRWPCLNVDISQGKGKKWWNLRKTCFTIVEHDWFETFIIFMILLSSGALAFEDIYIERRRTVKIVLEFADKVFTFIFVIEMLLKWVAYGFKTYFTNAWCWLDFFIVDISLISLSANLMGFSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGKFYRCINTTTAELFPISVVNNKSDCVALQEATQEARWVNVKVNYDNVAKGYLSLLQIATFKGWMDIMYPAVDSREVEEQPSYEINLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGDKDIFMTEEQKKYYEAMKKLGSKKPQKPIPRPANLIQGLVFDFISQQFFDIFIMVLICLNMVTMMVETDDQSPAKEDFLFKVNVAFIVVFTGECTLKLFALRHYFFTNGWNIFDFIVVILSIAGTMLSDIIEKYFVSPTLFRVIRLARIGRILRLIKGARGIRTLLFALMMSLPALFNIGLLLFLIMFIFSIFGMSNFAYVKKEAGINDMFNFETFGSSIICLFQITTSAGWDTLLLPMLNKEPPDCDPAFENPGTDVKGNCGNPMMGMVFFCSYIIISFLVVVNMYIAIILENFNVAQEESGDVLCEEDFEMFNETWEKFDTGGTQFIEYSQLSDFCDALQEPLRVAKPNRQRLIEMDLPLVIGDRIHCVDVLLAVTQEVLGDTIEMVAMRESIEAKFNLNNPTSASYAPITTTVRQKEEDMAAVVIQRAYRNHLHKRGIHHAAYIQRSKTGRKAASEDAPEKEGLLAKKMGALYGSDADLADEVEGLRRRPDPQTRCSGARCSPEPPEPNIILVPVEITNELLLHSAPSQQSSPTQTILRETNV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

muscle

DOI ID

10.1016/j.cub.2005.10.068